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  • Determination of trace elements in porcine brain by inductively coupled plasma mass spectrometry (ICPMS) and electrothermal atomic absorption spectrometry (ETAAS) and instrumental neutron activation analysis (INAA)

Abstract

Methods have been developed for the analyses of trace metals in various areas of porcine brains, (temporal, parietal, frontal cortex, both right and left hemispheres). Determinations were carried out using inductively coupled plasma-mass spectrometry (ICP-MS) and electrothermal atomic absorption spectrometry (ETAAs). The elements investigated were Li, Mn, Cu, Zn, Cd, Hg, and Pb by ICP-MS and Cu, Cd, and Mn by ETAAS. For determination by ICP-MS, a method of standard additions calibration coupled with internal standards was used, and for ETAAS, standard additions calibrations were prepared. The accuracy of all methods was determined using NISI and IAEA certified reference material.

A small number of pig brains were analyzed by instrumental neutron activation analysis for Cr, Co, Cs, Fe, Rb, Se, Sc, Sb, and Zn using the comparator method of analysis. Four separate NIST standard reference materials have been used to examine the validity of the comparator method..

Additional information

Authors: WHITE M.A, HSE, Sheffield (UK);SPYROU N.M, University of Surrey, Physics Department, (UK);PART P, JRC-CCR Environment Institute, Environmental Toxicology and Human Health, Ispra (IT);UBERTALLI L, JRC-CCR Environment Institute, Environmental Toxicology and Human Health, Ispra (IT);PANAYI A.E, JRC-CCR Environment Institute, Environmental Toxicology and Human Health, Ispra (IT)
Bibliographic Reference: An article published in: Biological Trace Element Research (1999) 71-72 pp.529-540
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