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This study investigates protein synthesis and sub-lethal Cu exposure in vivo and in vitro. In vivo only skin protein synthesis was reduced. Although this is a relatively sensing biomarker, the gills and liver were unaffected. Reductions in skin protein synthesis in vitro incurred increased synthesis costs whereas hepatocyte and gill cell protein synthesis costs were marginally affected. We hypothesise the energetic demand of protein synthesis determines tissue sensitivity Since much greater Cu concentrations were required to effect protein synthesis in vitro we also suggest the main use for cell cultures is in understanding toxicity mechanisms rather than for environmental monitoring.

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Authors: SMITH R.W, Department of Zoology, University of Aberdeen, Scotland (UK);BLANEY S.C, Department of Zoology, University of Aberdeen, Scotland (UK);HOULIHAN D.F, Department of Zoology, University of Aberdeen, Scotland (UK);DOWLING K, Radiation Science Centre, Dublin Institute of Technology (IE);STURM A, Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Leipzig (DE);JONSSON M,
Bibliographic Reference: An article published in: Elsevier, Aquatic Toxicology, 53 (2001), pp.265-277
Record Number: 200013606 / Last updated on: 2001-07-30
Original language: en
Available languages: en