In-house validation of a simplified method for the determination of PCBs in food and feeding stuffs
This paper comprises a simplified method for the determination of polychlorinated biphenyls (PCBs) in food and feeding stuffs. The method includes a cold column extraction step, a simple clean up with concentrated sulphuric acid and a final determination of the PCBs using gas chromatography-mass spectrometry (GC/MS). An in-house validation study was performed to establish method performance characteristics such as decision limit, detection capability, trueness and precision of the method. To determine these characteristics both certified reference materials and spiked samples were utilized. The outcome of the study clearly demonstrated that the method is fit for surveillance of PCBs in food and feeding stuffs, even though some care has to e taken to the solvent volume during the cold column extraction step as well as the addition of the standard to the sample. Additionally the investigation clearly demonstrates that in-house validation approaches may be used for determination of the overall performance of analytical methods.
Bibliographic Reference: An article published in: European Food Research Technology, Vol.213 (2001), pp.154-160
Record Number: 200113943 / Last updated on: 2001-10-24
Original language: en
Available languages: en