Preliminary results of the ECVAM validation study on three in vitro embryotoxicity tests
From 1996-2000 Zebet has coordinated the ECVAM (European Centre for the Validation of Alternative Methods) pre-validation and validation study of three embryotoxicity tests (embryonic stem cell test = EST, whole embryo culture = WEC, and the micromass assay = MM). The three in vitro embryotoxicity tests proved applicable to testing a diverse group of chemicals compromising different embryotoxic potential (none, weak/moderate, strong). The concordance between the embryotoxic potential derived from the in vivo data and from the in vitro data was very good. Applying the PM of the EST to in vivo data, in 78% of the experiments chemicals were classified correctly. For the MM and the WEC test the PMs provided 71% and 80% correct classification respectively and more importantly a predictivity of 100% was obtained with strong embryotoxic chemicals in each of the three assays.
Bibliographic Reference: An article published in: ALTA, Vol.29 (2001), pp.301-303
Record Number: 200114034 / Last updated on: 2001-11-14
Original language: en
Available languages: en