The use of in vitro models to study specific cellular mechanisms of tolerance to sub-lethal copper
The tissue specific effect of sub-lethal copper on protein synthesis in rainbow trout can be explained by determining the energetic cost of protein synthesis in different cell types in vitro. Cell or tissue types which are able to avoid an increase in the energetic cost of protein synthesis are those which are unaffected in vivo. In addition, gill cells are also able to down-regulate the cost of maintaining intracellular sodium. Therefore this data may demonstrate that energetic flexibility is the means by which fish are able to tolerate exposure to sub-lethal copper concentrations.
Bibliographic Reference: An oral report given at: The ECVAM Workshop on the Use of Fish Cells in Environmental Toxicology. Held in: Angera (IT), 22-24 October 2001
Record Number: 200114084 / Last updated on: 2001-11-23
Original language: en
Available languages: en