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Abstract

The Institute for Reference Materials and Measurements and the International Federation of Clinical Chemistry Laboratory Medicine (IFCC) characterized and certified a reference material under the name and number IRMM/IFCC-456. This report describes the certification of the catalytic concentration of alpha-amylase in a purified lyophilised material of human origin (pancreas) in a human serum albumin matrix when measured by the IFCC reference method at 37 C. The catalytic concentration of amylase in reconstituted material is certified to 546 +/- 19 U/L or 9.1 +/- 0.3 micro-kat/L. It is the intention that the reference material should be used to control and optimise the performance of enzyme measurements, verify the comparability of results from different laboratories and be used as a reference material for manufacturers of reagents and diagnostic kits.

Additional information

Authors: LINSINGER T, JRC, Institute for Reference Materials and Measurements, Geel (BE);SCHIMMEL H, JRC, Institute for Reference Materials and Measurements, Geel (BE);PAUWELS J, JRC, Institute for Reference Materials and Measurements, Geel (BE);SCHUMANN G, Deutsche Gesellschaft für Klinische Chemie e V, Reference Institute of Bioanalysis, Bonn (DE);SIEKMANN L, Deutsche Gesellschaft für Klinische Chemie e V, Reference Institute of Bioanalysis, Bonn (DE);CERIOTTI ET AL, International Federation of Clinical Chemistry Laboratory Medicine
Bibliographic Reference: EUR 19927 EN (2001), pp. 18. Euro: Free of charge
Availability: Available from JRC Information & Public Relations Unit, European Commission. Fax: +32-2-2996322 and JRC Information & Public Relations Unit, Ispra (IT)
ISBN: ISBN 92-894-1980-6
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