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Abstract

An LC-MS/MS method has been validated for the simultaneous quantification of eleven (fluoro)quinolone antibiotics at the maximum residue level (MRL) in swine kidney. The studied compounds were danofloxacine, cinoxacine, ciprofloxacine, enoxacine, enrofloxacine, flumequine, marbofloxacine, nalidixic acid, norfloxacine, ofloxacine and oxolinic acid. The method involves the solid-phase extraction (SPE) of these compounds followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis using an electrospray ionisation (ESI) interface. Limits of quantification (LOQs) = 50 µg.kg(-1) could be obtained in swine kidney, much lower than every MRL. The validation is discussed. This work was carried out to support the European Commission policy on consumer health protection.

Additional information

Authors: RODRIGUEZ A, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);BORDIN G, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);JANOSI A, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);TOUSSAINT B, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE)
Bibliographic Reference: An oral report given at: Seventh International Symposium on Hyphenated Techniques in Chromatography (HTC-7) Organised by: Royal Flemish Chemical Society (KCCV) Held at: Brugge (BE), 6-8 February 2002
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