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  • Good Cell Culture Practice (GCCP) - an initiative for standardisation and quality assurance of in vitro studies. The establishment of an ECVAM Task Force on GCCP

Abstract

Cultured human and animal cells are increasingly used as the basis for simplified, direct test systems that have the potential to be more controllable and more reproducible than in vivo test systems. However, the essential components of such a reduced system must be closely defined and reproducible. Thus, minimal requirements for quality standards in cell and tissue culture have to be defined. It is the aim of this GCCP initiative to establish principles for standardisation, rationalisation, and international harmonisation of cell and tissue culture laboratory practices. Therefore, in analogy to Good Laboratory Practice (GLP), a Good Cell Culture Practice (GCCP) was initiated at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, 29.08.1999 - 02.09.1999. This "Bologna Statement on Good Cell Culture Practice" was presented, discussed, and refined in a workshop, and a final version was approved at the closing ceremony of the Congress. Based on the Bologna Statement, an ECVAM Task Force on GCCP was initiated that is chaired by Thomas Hartung and Sandra Coecke, in which experts in the field should elaborate minimal requirements for quality standards in cell culture. It is the intention of the GCCP Guidelines to encourage consensus among all concerned with the use of in vitro systems, in order to establish and maintain best laboratory practices, to promote effective quality control systems, to facilitate education and training, to support journal editors, and to help any authorities who need to interpret and apply conclusions based on in vitro data.

Additional information

Authors: HARTUNG T, Biochemical Pharmacology, University of Konstanz (DE);GSTRAUNTHALER G, Institut für Physiologie, Universität A-Innsbruck (AT);COECKE S, European Commission, Joint Research Centre, Institute for Health & Consumer Protection, ECVAM, Ispra (IT);BALLS M, European Commission, Joint Research Centre, Institute for Health & Consumer Protection, ECVAM, Ispra (IT);LEWIS D, ECACC, CAMR, Salisbury (GB);BLANCK O, Pfizer, Amboise (FR)
Bibliographic Reference: An article published in: Altex, 18, 1/01, pp. 75-78
Record Number: 200214696 / Last updated on: 2002-05-15
Category: PUBLICATION
Original language: de
Available languages: de