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An international ring-test of the enchytraeid reproduction test was performed by 29 laboratories, with two substances (Carbendazim and 4-Nitrophenol) and two test designs (NOEC and ECx). The majority of tests were performed accurately and fulfilled the validity criteria, demonstrating method feasibility. However, variability in control reproduction was fairly high, and exceeded the proposed validity criterion. In all tests NOECs were higher than the EC{10} values, sometimes by more than one order of magnitude, and usually closer to the EC{50}. This shows that NOECs are an unsatisfactory measure of "no toxicity" for regulatory purposes due to their dependence on test design and variability.

Additional information

Authors: WEYERS A, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, European Chemicals Bureau, Ispra (IT);RÖMBKE J, ECT Oekotoxikologie GmbH, Flörsheim am Main (DE);MOSER T, ECT Oekotoxikologie GmbH, Flörsheim am Main (DE);RATTE H T, Aachen University of Technology, Aachen (DE);ROMBKE J, ECT Oekotoxikologie GmbH, Florsheim am Main (DE)
Bibliographic Reference: An article published in: Environmental Science & Technology, Vol. 36, No. 10, May 15, 2002, pp 2116 - 2121
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Record Number: 200214984 / Last updated on: 2002-08-19
Original language: en
Available languages: en