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Abstract

Boron Neutron Capture Therapy (BNCT) is based on two important issues: a neutron flux characterized by a suitable spectrum and a {10}B carrier able to locate in proximity to the tumour cells. The knowledge of the precise localization of the boron atoms is fundamental during the treatment planning. Nowadays, Positron Emission Tomography (PET) is able to provide this in vivo information. The idea of coupling the Treatment Planning System (TPS) to the information on the real boron distribution in the patient is the main added value of the PET-based TPS methodology, in comparison to the standard TPS, which unrealistically assumes a uniform boron distribution.

A new TPS, based on the Monte Carlo technique, has been developed in order to demonstrate the feasibility of this advanced methodology and to initiate a promising branch in the BNCT research. The validation of the new TPS, called BDTPS (Boron Distribution Treatment Planning System), has been conducted comparing the main BNCT parameters (thermal flux, boron dose, etc.) as measured during the irradiation of a special heterogeneous boron phantom (HEBOM), ad hoc designea: as calculated by the BDTPS and by the standard TPS, SERA. Major SERA errors have been found especially in the calculation of the boron dose, which is the most important parameter in BNCT. For example, the patient irradiation time is determined on the grounds of this value. Therefore the best knowledge of the boron dose during the treatment planning is a crucial issue in view of a proper BNCT protocol.

Additional information

Authors: DAQUINO G G, Universitá degli Studi di Pisa, Facoltá di Ingegneria, Pisa (IT);No author stated, European Commission, Joint Research Centre, Institute for Energy, High Flux Reactor and Reactor Applications Unit, Petten (NL)
Bibliographic Reference: EUR 20678 EN (2003), 298pp. Free of charge
Availability: EUR-OP reference: LD-NA-20678-EN-C Available from European Commission, JRC Information & Public Relations Unit, Ispra (IT) Fax: +39 033278 5409 or Fax: +32 2 2996322 E-mail: jrc-publications-office@ec.europa.eu
ISBN: ISBN: 92-894-5507-1
Record Number: 200316593 / Last updated on: 2003-08-29
Category: PUBLICATION
Original language: en
Available languages: en