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Abstract

Chronic exposure to arsenic has been associated with a variety of adverse health effects. Environmental arsenic exposure mainly occurs through ingestion of contaminated water, particularly in regions with geological sources of this toxic compound. The mechanisms involved in arsenic toxicology are not well understood and represent a major uncertainty factor in risk assessment for regulatory actions on drinking water quality. Identification of genes whose expression is specifically modulated by arsenic exposure would provide a better understanding of its mechanisms of action and allow the identification of sensitive and specific biomarkers of both exposure and susceptibility. Specific biomarkers of exposure/effect, and susceptibility are needed in epidemiological studies assessing human health impact. Systematic studies of gene expression patterns have been proposed as a new powerful tool in environmental toxicology.

In this communication we report and discuss the modulation of the genes involved in carcinogenetic mechanisms detected in urinary bladder of male and female mice chronically exposed to 1 mg/L of arsenic as sodium arsenate or as dimethylarsinic acid (DMA), one of its main cellular metabolite and a food contaminant. These results are part of a larger study on target arsenic tissues in mice exposed during different growing stages to arsenicals in drinking water.

Additional information

Authors: CASATI B, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra (IT);COLLOTTA A, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra (IT);MARAFANTE E, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra (IT);CLERICI L, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, Ispra (IT)
Bibliographic Reference: EUR 20778 EN (2003), 73pp. Free of charge EUR-OP reference: LB-NA-20778-EN-C
Availability: Available from European Commission, JRC Knowledge Management Unit, Ispra (IT) Tel: +39 033278 9843 or +39 033278 9864 Fax: +39 033278 9623 E-mail: jrc-publications-office@ec.europa.eu
ISBN: ISBN: 92-894-6038-5
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