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  • Certification of the clenbuterol mass concentration in lyophilised bovine liver reference materials + indicative information on salbutamol and terbutaline mass concentrations. BCR-648 (beta-agonist-free) and BCR-649 (beta-agonist positive)


Agonists of Beta-andrenergic receptors are illegally used as repartitioning agents of fat and as growth promoters and production enhancers in meat-producing animals. Beta-agonists are not permitted as veterinary drugs with the exception of clenbuterol, which is authorised, in the European Union, only under certain conditions in cows and in horses for zootechnical and therapeutic purposes (Directive 92/22/EC). Their residues are controlled in urine, bile, liver and eye or hair samples.

This contribution describes the production and certification of lyophilised bovine liver materials uncontaminated (BCR-648) or contaminated (BCR-649) with clenbuterol, salbutamol and terbutaline residues.

Additional information

Authors: GASPAR P ET AL, Laboratory of Analysis of Foodstuffs of Animal Origin, Faculty of Veterinary Medicine, University of Liège (BE);KRAMER G N ET AL, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);VAN GINKEL L A, National Institute of Public Health and Environment (RIVM), Laboratory for Residue Analysis, Bilthoven (NL);DIRSCHERL C, European Commission, DG Research, Standards, Measurement and Testing, Brussels (BE)
Bibliographic Reference: EUR 20526 EN (2003), 49pp. Free of charge
Availability: Available from European Commission, JRC Knowledge Management Unit, Ispra (IT) Tel: +39 033278 9843 or +39 033278 9864 Fax: +39 033278 9623 E-mail:
ISBN: ISBN: 92-894-4657-9
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