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Abstract

The purpose of the analyses presented in this report was to contribute to an evaluation of the possibility of using QSAR predictions for regulatory purposes. To this end QSAR predictions were compared with SIDS test data. Furthermore, the models were also assessed according to the extent to which they meet OECD principles for QSAR validation (OECD ENV/JM/Mono(2004)24). It is emphasized that the comparisons are not intended to be scientific validations, because the SIDS test chemicals were not selected to ensure that they are sufficiently diverse and representative for the entire applicability domain of the individual models. Nevertheless, many of the analyses presented here form the basis for scientific validation.

Additional information

Authors: PAVAN M, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT);WORTH A, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT);NETZEVA T, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT)
Bibliographic Reference: EUR 21750 EN (2005), 120 pp. Free of charge
Availability: Available from European Commission, JRC Knowledge Management Unit, Ispra (IT) Tel: +39 033278 9893 Fax: +39 033278 5409 E-mail: jrc-publications-office@ec.europa.eu or Bruxelles (BE) Tel: +32 2 295 76 24 Fax: +32 2 299 63 22
Record Number: 200618495 / Last updated on: 2005-12-15
Category: PUBLICATION
Original language: en
Available languages: en
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