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FP7

Biodegradable radioactive implants for glaucoma filtering surgery produced by ion implantation

Funded under: FP7-EURATOM

Abstract

A biodegradable, beta-emitting implant has been developed and successfully tested which prevents fresh intraocular pressure increase after glaucoma filtering surgery. Ion implantation has been used to load the polymeric implants with the beta-emitter {32}P. The influence of ion implantation and gamma sterilisation on degradation and {32}P-fixation behavior has been studied by ion beam and chemical analysis. Irradiation effects due to the applied ion fluence (10{15} ions/cm{2}) and gamma dose (25 kGy) are found to be tolerable.

Additional information

Authors: ASSMANN W, Department für Physik, Ludwig-Maximilians-Universität München, Garching (DE);SCHUBERT M, Department für Physik, Ludwig-Maximilians-Universität München, Garching (DE);HELD A, Augenklinik, Technische Universität München, München (DE);PICHLER A, Augenklinik, Technische Universität München, München (DE);LANZL I, Augenklinik, Technische Universität München, München (DE);CHILL A, Zentralinstitut für Medizintechnik, Technische Universität München, Garching(DE);KIERMAIER S, Zentralinstitut für Medizintechnik, Technische Universität München, Garching(DE);SCHLÖSSER K, Forschungszentrum Karlsruhe, Karlsruhe (DE);BUSCH H, NTTF GmbH, Rheinbreitbach (DE);SCHENK K, NTTF GmbH, Rheinbreitbach (DE);STREUFERT D, Acri.Tec GmbH, Hennigsdorf (DE)
Bibliographic Reference: An article published in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Volume 257, Issues 1-2 (2007), pp 108-113
Availability: This article can be accessed online by subscribers, and can be ordered online by non-subscribers, at: http://dx.doi.org/doi:10.1016/j.nimb.2006.12.155
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