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  • Certification of the amount-of-substance fraction of HbA1c versus the sum of all Hb isoforms forming the glycated or non-glycated N-terminal hexapeptide of the beta -chain in haemoglobin [...]

Abstract

Certification of the amount-of-substance fraction of HbA1c versus the sum of all Hb isoforms forming the glycated or non-glycated N-terminal hexapeptide of the beta -chain in haemoglobin isolated from whole blood, IRMM/IFCC-466
This report describes the preparation, homogeneity, stability and certification studies as well as the purity evaluation of highly purified HbA1c (IRMM/IFCC-466) from human blood. HbA1c is defined as the stable adduct from glucose and the Nterminal amino group of the ß-chain of haemoglobin A0 that is beta-N-(1-deoxyfructos-1-yl) haemoglobin [1]. A description of the analytical methods used in each of these studies is included. All relevant data from the homogeneity and stability studies as well as those for the characterisation measurements are presented.

Additional information

Authors: MUÑOZ-PIÑEIRO A, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);SCHIMMEL H, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);KLEIN C, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE)
Bibliographic Reference: EUR 22795 EN (2007), 29 pp. Free of charge
Availability: Available from European Commission, JRC Knowledge Management Unit, Ispra (IT) Tel: +39 033278 9893 Fax: +39 033278 5409 E-mail: jrc-info@ec.europa.eu or Bruxelles (BE) Tel: +32 2 295 76 24 Fax: +32 2 299 63 22
ISBN: ISBN: 978-92-79-06159-2
Record Number: 200719525 / Last updated on: 2007-10-29
Category: PUBLICATION
Original language: en
Available languages: en