Community Research and Development Information Service - CORDIS

FP7

Review of data sources, QSARs and integrated testing strategies for skin sensitisation

Funded under: FP7-JRC

Abstract

This review collects information on sources of skin sensitisation data and computational tools for estimation of skin sensitisation potential, such as expert systems and (quantitative) structure-activity relationship (QSAR) models. The review also captures current thinking of what constitutes an integrated testing strategy (ITS) for this endpoint. The emphasis of the review is on the usefulness of the models and for the regulatory assessment of chemicals, particularly for the purposes of the new European legislation for the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), which entered into force on 1 June 2007. Since there are no specific databases for skin sensitisation currently available, a description of experimental data found in various literature sources is provided. General (global) models as well as models for specific chemical classes and mechanisms of action are summarised. This review was prepared as a contribution to the EU funded Integrated Project, OSIRIS.

Additional information

Authors: PATLEWICZ G, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT);WORTH A, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT)
Bibliographic Reference: EUR 23225 EN (2008), various paging, Free of Charge
Availability: http://bookshop.europa.eu/is-bin/INTERSHOP.enfinity/WFS/EU-Bookshop-Site/en_GB/-/EUR/ViewPublication-Start?PublicationKey=LBNA23225 (Catalogue Number: LB-NA-23225-EN-C)
Record Number: 200819953 / Last updated on: 2008-07-28
Category: PUBLICATION
Original language: en
Available languages: en