Community Research and Development Information Service - CORDIS


Antimicrobial resistance

Funded under: FP7-HEALTH


Once easily mastered through the administration of antibiotics, severe hospital- and community-acquired bacterial infections are on a sharp rise in Europe due to increasing resistance against available antibiotics. At the same time, the drug development pipeline for new antibiotics is virtually empty because of a lack of incentives for the pharmaceutical industry to invest in this field. In the longer term perspective, difficulties in effectively treating bacterial infections pose a threat to many modern diagnostic and treatment modalities.
Research to combat the growing problem of antimicrobial drug resistance (AMDR) has been a high priority on the agenda of the EU Framework Programmes ever since the Microbial Threat Conference in Copenhagen in 1998. The goal of the EU research in this area is to generate scientific evidence for the policies, strategies and practices for countering AMDR in and beyond the EU.
The Health Directorate of DG RTD supports multidisciplinary collaborative research in several interdependent areas of the AMDR problem. Studies of basic phenomena of drug resistance focus on molecular mechanisms of host-parasite interactions that lead to the emergence and spread of resistance genes. Epidemiological studies unravel the dynamics of the distribution of multi-drug resistant strains of pathogens in human populations with the aim of developing control and preventive measures. Translational research merges basic science of microbial and human genomics with clinical and public health research for developing guidelines for evidence-based clinical practice and patient management, and in particular, for prudent use of antibiotics. To promote the rational use of antibiotics, the European biotechnology industry is mobilized to develop point-of -care diagnostic tests for early identification and differentiation of the disease-causing agents.

Additional information

Authors: No author stated, European Commission, DG Research, Brussels (BE)
Bibliographic Reference: Luxembourg, Office for Official Publications of the European Communities, 2008. various paging, free of charge
Availability: (Catalogue Number: KI-81-08-376-EN-C)
ISBN: ISBN: 978-92-79-09803-1
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