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FP6

EU Workshop Report on European Database and Analysis Resources for Research in Human Genetic Variation, Based upon a Workshop held in Brussels, Belgium on 2-3 March 2006

Funded under: FP6-LIFESCIHEALTH

Abstract

The need for unification of databases focusing on human genetic variation and associated phenotype links has been recently highlighted in a Nature Genetics editorial and elsewhere. Until now, no effective strategy for achieving this has been formulated. Existing collections of genetic relationships, predominantly from Mendelian single gene variation traits, when supplemented by information from model organisms, have provided many fundamental insights into human biology, at both the body and cellular levels. Differences between healthy people, and also causes of diseases, have some genetic component. If all aspects of the genetic contribution could be identified, they would lead to advances in biomedical research, as well as furthering the cataloguing of human genotype-phenotype relationships. Nevertheless, the workshop participants strongly supported the thesis that the lack of data integration inhibits many research breakthroughs.
An integrated genetic variation catalogue would be an immense boon to bioresearch, in areas such as: general understanding of human physiological processes in both health and disease; the ability to analyse populations according to different classifications; the diagnosis and treatment of disease.
An workshop of leading European bioinformaticians, biologists, medical researchers and clinicians was held in Brussels on 2-3 March 2006 to examine if strategies could be identified. The conclusion was that an integrated database and analysis structure for much of human and model organism variation genetics should be achieved by database linking at a European level, and in the near future, by means of a pragmatic and step-by-step approach.

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Record Number: 7373 / Last updated on: 2006-05-15
Category: PROC
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