Community Research and Development Information Service - CORDIS

FP5

DNA damage response mechanisms in radiation protection (DNA Damage Responses), Final report (summary)

Project ID: FIGH-CT-1999-00010
Funded under: FP5-EAECTP C

Abstract

Rational judgements in radiation protection require a detailed knowledge of the basic mechanisms by which radiation induces cancer and genetic disorders. The identification of most of the genes involved in DNA damage responses to ionising radiation and the generation of knockout mice defective in these processes provide the basis for unravelling the mechanisms of the different DNA damage response pathways and their interactions. Based on these results, genes in three pathways for the repair of DNA double-strand breaks (the most critical lesion after ionising radiation, IR) have been identified, namely homologous recombination, DNA end-joining and replication-associated repair.
In this project we exploited new technologies (e.g. scanning force microscopy, DNA chips, proteomics, fluorescent redistribution after photo bleaching) and utilised a number of different organisms (human, mouse, Drosophila, Xenopus, C. elegans, budding and fission yeast) to further dissect the mechanistic pathways. To carry out the research plan, the work was divided into five different work packages. Six laboratories were involved to carry out the various aspects.

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Record Number: 8914 / Last updated on: 2008-01-23
Category: PRJS