Improved cancer risk quantification for environmental, medical and occupational exposures to low doses of ionising radiation by mechanistic models (Low Dose Risk Models), Final report (summary)
Project ID: FIGH-CT-1999-00005Funded under: FP5-EAECTP C
This project has contributed to the solution of the important open problem of quantification of somatic radiation risks to humans at low doses (below, say, 10 mSv) and low dose rates of ionising radiation of various qualities at least for the organs lung, liver and bone. Since this problem cannot be solved by basic biological investigations or by epidemiological studies alone, the scientific knowledge from both areas has been combined to develop and test quantitative mechanistic models for the dose-time-effect surfaces of radiation carcinogenesis in these organs. Existing data and theories were evaluated and used for the modelling of radiation transport and interaction, for the modelling of subsequent damage and repair of DNA, genes, cells and organs taking normal oxidative damage into account, and for the multistep modelling of carcinogenesis. Conclusions were drawn for the general radiation protection of the worker and the public.
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Record Number: 8929 / Last updated on: 2008-01-24