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Identification and isolation of susceptibility genes involved in radiation-induced cancer in humans (SUS GENES IN RAD CAR), Final report (summary)

Project ID: FIGH-CT-1999-00002
Funded under: FP5-EAECTP C


Humans are exposed to ionising radiation (IR) from natural (e.g. cosmic radiation, radon) as well as man-made (e.g. diagnostic X-rays, radiotherapy) sources. With nuclear power likely to assume increasing importance in EU countries during the coming decades as global oil reserves are depleted (for a recent review, see Nature 424, 129, 2003), the precise mechanisms by which IR acts as a human carcinogen will become even more urgent, particularly with respect to the carcinogenicity of low-level radiation exposures. To be properly able to anticipate the risks of ionising radiation exposure and provide updated safety advice both to the public and to those whose work exposes them to IR, a detailed understanding of mechanisms is essential. For example, a great deal more by way of hard scientific information is needed about the nature of the molecular genetic alterations involved in radiation-induced cancer in humans. Identification of the key target genes and associated cellular pathways will furnish a basis for epidemiological studies, using novel molecular information, aimed at determining the precise role of ionising radiation in the development of human cancers. It may also lead to rapid screening procedures for predicting individual risk. This was the overall aim of the project SUS GENES IN RAD CAR.

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Record Number: 8932 / Last updated on: 2008-01-24
Category: PRJS