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  • Genetic pathways for the prediction of the effects of irradiation European Normal and Tumour Tissue Bank and Database (GENEPI-ENTB), Final report (summary)
FP5

Genetic pathways for the prediction of the effects of irradiation European Normal and Tumour Tissue Bank and Database (GENEPI-ENTB), Final report (summary)

Project ID: FIR1-CT-2002-20213
Funded under: FP5-EAECTP C

Abstract

The European tissue bank and database GENEPI-ENTB is dedicated to research in radiation effects and in the genetic determinants of the variation in individual radiosensitivity. The primary aim of GENEPI-ENTB was to create a tissue bank linked to a detailed outcome database of a large cohort of patients receiving radiotherapy and the development of a lymphocyte tissue bank containing samples from a cohort of large kindred French families, equally linked to a database. For that reason it was planned to establish a central database providing links to existing decentral databases and tissue banks, enabling optimal utilization and access to data and material. It was GENEPI-ENTB's aim to network fragmented research efforts in this way, to open up often dormant resources in comprehensive cancer centres for well-equipped laboratories with no access to clinical facilities (such as nuclear research centres), and to create a high-quality shared infrastructure for projects dedicated to radiation research.
From the start it was decided that the tissue bank would remain open for at least 20 years, thus providing an excellent resource for future genetic research in the field of health risks linked to occupational, environmental, and medical exposure at all dose levels.
To guarantee the quality of GENEPI-ENTB, dummy runs with modern statistical tools were planned to monitor the quality of this novel research infrastructure as well as the development of protocols for outcome assessment, tissue handling, and use and access of the infrastructure.
Another objective of GENEPI was to create a frame of reference for researchers who want to exchange tissue in the context of the GENEPI resource and to address the relevant ethical and legal issues to ensure that the project would be handled in compliance with all existing legislation and appropriate legal and ethical standards.

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Record Number: 8955 / Last updated on: 2008-02-13
Category: PRJS
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