Community Research and Development Information Service - CORDIS

FP5

Radiosensitivity, Heritability and Genetics (RaHGe), Final report (summary)

Project ID: FIGH-CT-2002-00216
Funded under: FP5-EAECTP C

Abstract

The benefits of ionising radiation in the field of energy production, food sterilisation, industrial applications, diagnostic and therapeutic medical procedures are often obscured by late effects of unintended or intended exposure that tend to attract large media attention. Some individuals may have a disproportionately high risk of incurring radiation damage as a result of environmental, occupational, accidental or medical exposure. If these individuals could be identified, the risk of adverse effects can be considerably reduced thus making more acceptable these industrial or medical procedures. Previous research indicates that genetic predisposition could play an important role in radiosensitivity. The RaHGe study aimed at establishing biological resources to measure the relative contribution of environment and genetic predispositions to radiosensitivity. Subsequently, these will be used to initiate the identification of the genetic polymorphisms and, eventually, gene expression profiles involved in radiation senstivity. This work could result in tests enabling a better prediction of susceptibility of the individual to radiation effects. Outcomes of the RaHGe project could therefore ultimately help to improve the quality of industrial and medical uses of radiation.

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