Community Research and Development Information Service - CORDIS


Active Biomimetic Systems (ACTIVE BIOMICS) - Publishable Executive Summary

Project ID: 516989
Funded under: FP6-NMP


The "Active biomimetic systems" studied in this STREP are built up from two types of molecular machines, growing filaments and stepping motor proteins. Growing filaments generate pushing forces; stepping motor proteins exert pulling forces. The first objective of this STREP, which started on May 1, 2005, is to elucidate these force generation mechanisms and to obtain a systematic understanding of the corresponding molecular processes.
Because of its small size, a single molecular machine generates rather small forces and is easily perturbed by thermal noise. In order to have some appreciable 'impact' onto their surroundings, these molecular machines have to act in groups. Therefore, the second objective of this STREP is to study and clarify the cooperative behavior of small and large groups of molecular machines.
The third objective, which applies both to the single motor properties and to the cooperative behavior of many motors, is to control and to vary the system properties in a reliable and systematic manner. Thus, the different projects in this STREP have the common target to control and maximize the generated forces, to control and optimize the transport properties, and to vary the architecture of the filament/motor assemblies in a controlled manner.

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