Community Research and Development Information Service - CORDIS


Nanobiotechnology with Self-Organising Structures (NABIS) - Publishable Executive Summary

Project ID: 505311
Funded under: FP6-NMP


The goal of the NABIS research project; a three years effort which started in January 2004, is to study and develop novel synergistic technologies for development of the next generation of high performance biochips. These chips are anticipated to become very important in areas like accelerated drug discovery, diagnostics and personalized medicine. One of the key technologies relies on a predictable self-organization of fluids, where both static and dynamic formats are developed. The formats will be combined to overcome current bottlenecks in the automation of high throughput assays, and will also be used for the development of a new concept for automated chip replication. Other complementary technologies deal with surface expanded high density bioprobe arrays, including the use of novel polymers. Also, novel magnetic bio nanowires, controlled by an external magnetic field onto a platform of magnetic nanodots, are being explored. It is anticipated that the use of these technologies will provide a possibility for a controlled increase of ligand density, as well as enhanced kinetics, resulting in improved sensitivity and faster assay performance. A third technology based on externally applied surface acoustic waves is also incorporated into the platform, yielding efficient agitation of nanodroplets. Finally, a nanoelectrochemical detection system will be developed. The technologies will be combined to yield an optimized biochip which will be tested using standard bioassays, and the results obtained will be compared with performance data, obtained from similar experiments with state of the art biochips.

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