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FP6

Self-reporting biological nanosystems to study and control bio-molecular mechanisms on the single molecule level (BIOSCOPE) - Final Publishable Report

Project ID: 505211
Funded under: FP6-NMP

Abstract

The aim with BIOSCOPE was to pioneer the development of new leading edge nanoscale research tools and methodologies that will allow unprecedented insight into bio-molecular mechanisms at biological interfaces on the molecular scale.
BIOSCOPE consider the biomolecular system itself as a part of the nanoscopic instrument, which in various ways reports to the out-side world about its current local state. Thereby it will be possible to study the local effects on the molecular level when e.g. a protein interacts with a biomembrane surface or when a lipase interacts with a lipid surface. The objectives of BIOSCOPE were:
- To develop instrumentation and methods for manipulation of enzymes and enzyme activity at the nanoscale providing insight into the biomolecular mechanisms on a single molecule level.
- To develop novel forms of integration, at the nanoscale level, of enzymes and non-biological systems such as nanoparticles, artificial membranes, electrical field or force field traps.
- To confine several enzymes to surfaces of nanoparticles or membranes on a less than 10 nm scale in order to achieve a self-organized assembly with a concerted bioaction superior to the simple sum of the same individual enzymes. The function of the nanosystems will be optimized for enzymatic action on biosubstrates.

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Record Number: 9478 / Last updated on: 2008-10-30
Category: PROJ
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