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  • Addressable Molecular Node Assembly - a Generic Platform of Nano-scale Functionalised Surfaces Based on a "Digitally Addressable" Molecular Grid (AMNA) - Publishable Executive Summary
FP6

Addressable Molecular Node Assembly - a Generic Platform of Nano-scale Functionalised Surfaces Based on a "Digitally Addressable" Molecular Grid (AMNA) - Publishable Executive Summary

Project ID: 13575
Funded under: FP6-NMP

Abstract

The goal of the program is a nano-technology platform based on a 100 nm size grid of addressable molecular building blocks ("nodes") to constitute a bottom-up modular approach to place functional groups at defined positions in space with sub-nm precision. An almost complete freedom of choice, for grid assembly as well as for positioning of functional groups, is based on a "digital" (in contrast to analog) code for molecular recognition. This is achieved using DNA base-pair recognition. After the two first years of the project we have among other things developed novel three-way DNA monomers that subsequently efficiently can be incorporated into trigonal DNA oligonucleotides using standard solid-phase synthesis. Each of these nodes has three oligonucleotide arms so that a group of six nodes are connected into a hexagon. Also, these trigonal nodes have been functionalised with fluorescent moieties and/or lipid anchoring groups for future functionalisation and attachment/anchoring of the DNA nano-network.

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