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  • Alternative Testing Strategies Progress report2009. Replacing, Reducing And Refining Use Of Animals In Research. Genomics & Biotechnology. Eur 23886
FP6

Alternative Testing Strategies Progress report2009. Replacing, Reducing And Refining Use Of Animals In Research. Genomics & Biotechnology. Eur 23886

Project ID: 503257
Funded under: FP6-LIFESCIHEALTH, FP7-HEALTH

Abstract

ReProTect assembles 33 different European partners from Academia, Industry including small to medium-sized enterprises (SMEs) and Governmental Institutes. Due to the Registration, Evaluation and Authorisation of Chemicals (REACH) Regulation and the seventh Amendment of the Cosmetic Directive implementation, a dramatic increase in animal consumption for toxicity safety testing is expected. It is estimated that around 5000 chemicals will require testing for reproductive and developmental toxicity.
As a consequence, millions of animals will be sacrificed for the identification of reproductive toxicants. Moreover, it has been calculated that ~60% of the total costs of the REACH exercise will be with reproductive toxicity studies. on the other hand, the new European legislation itself asks for the use of alternative methods rather than for the application of conventional testing designs for the thousands of chemicals to be tested. For this reason, the integration of alternative tests in a testing strategy that will
use existing information from animal studies and integrate additional information from alternative tests for reproductive toxicity (in vitro tests, QSARs and read-across approaches) is strongly encouraged. on this background, the overall aim of ReProTect is to develop new in vitro models and to improve existing ones,in order to include them into a testing strategy, which aims to provide detailed information on the hazard
of compounds to the mammalian reproductive cycle.

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