Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Non-invasive monitoring of the autonomic nervous system and the cardiovascular system

The main field of research is the in vivo noninvasive investigation and assessment of the autonomic nervous system and the cardiovascular system. The group has conducted extensive studies related to investigating the possibility of the early detection of physiological changes associated with diabetes neuropathy by making measurements on juvenile diabetics. On the basis of data from hundreds of patients, the group has designed and built 5 novel pieces of experimental computerized electronic equipment. In addition, the group is collaborating with other researchers and clinical investigators to investigate the possibility of developing a sensitive technique and method of in vivo monitoring for the onset of hypoglycaemia, by extracting hidden information both from the real time skin transient pulse blood (STPB), detected absorption, and from the response waveform as a whole of the transient signal of the skin sympathetic sudomotor activity, detected as skin electrical impedance. This project involves the application of bioelectronics and information technology in the in vivo sensing of glycaemia. The personal computer (PC) based system developed by the group supports a variety of analysis programs which have been instrumental to the success of its research efforts. Because of this, the results obtained have indicated the suitability of the use of the fast Fourier transform (FFT) analysis of STPB to the assessment of the autonomic cardiac dysfunction, and that it is possible to easily, rapidly and non-invasively distinguish between the sympathetic and parasympathetic cardiac activity significantly improving cardiovascular diagnosis by lowering both the cost of diagnosis and the discomfort to the patient. With the development of a new PC based system it has been possible to study the reaction of the autonomic nervous system to blood sugar concentration experienced in hypoglycaemia. Preliminary in vivo evidence has confirmed that insulin can have a direct effect on cardiovascular dynamics and particularly on blood pressure, heart rate, sudomotor activity, vasomotor activity etc.

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