Final Report Summary - MOBODICT (Noninvasive Monitoring of Blood Flow and Oxygen Dynamics as Biomarkers in Cancer Tumours) Diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) are optical techniques that can be used to study haemoglobin concentration, oxygenation and blood flow in biological tissue non-invasively and in vivo. In this project we use these techniques to study physiological changes in tumours. In particular;• We have developed a non-contact system to study of experimental therapies on xenoimplanted tumours in mice allowing for monitoring of physiological changes in them due to therapy without the need to sacrifice animals at several time-points.• We have development and used a Monte Carlo package for light transport simulations to aid the analysis and design of the optical systems. The code is particularly designed to allow simulation of both DCS and broadband or time-resolved DOS in arbitrary geometries, e.g. from MRI, and will be publicly available for other research groups when finished. • We used these tools to study of antiangiogenic therapy on renal cell carcinoma in mice to obtain important insight in the mechanics of antiangiogenic therapy and be able to detect therapy resistance early-on.• Finally, we have explored the utility of these techniques in superficial cancers in the neck region.
