Community Research and Development Information Service - CORDIS

FP7

OncoGeneRegulation Result In Brief

Project ID: 293829
Funded under: FP7-PEOPLE
Country: Turkey

New molecular targets for melanoma treatment

Advanced deadly forms of melanoma are resistant to current therapies. Better understanding of the regulatory circuits of melanoma development helps to identify novel therapeutic targets.
New molecular targets for melanoma treatment
Interferon regulatory factor 4 (IRF4) is a transcriptional regulator with a critical role in lymphocyte development and function. Recent evidence shows that it plays a major role in lymphoma and multiple myeloma.

In several studies, high IRF4 expression is also associated with certain forms of melanoma-type skin cancer. Additionally, IRF4-linked polymorphisms seem to contribute to pigmentation, nevi count and risk of developing melanoma. However, the precise molecular mechanisms behind the role of IRF4 in melanoma and melanocyte biology are currently unknown. The scope of the EU-funded ONCOGENEREGULATION (Dissecting the genome-wide action of interferon regulatory factor 4 (IRF4) in melanoma) project was to investigate the role of IRF4 in melanoma cells using cellular, molecular, and genome-wide approaches.

During the first part of the project, scientists tested the requirement for IRF4 in the survival and proliferation of melanoma cells using RNA interference technology. The results confirmed that IRF4 is indeed a critical factor for melanoma cells.

During the final stage of the project, researchers characterised the genes and pathways controlled by IRF4 in melanoma cells using genome-wide gene expression profiling. This study provided new leads and a subset of these genes was confirmed using gene-specific assays.

The results of the ONCOGENEREGULATION project provide evidence that IRF4 is a critical regulator of melanoma progression at the cellular level. This study improves our understanding of melanoma biology and might lead to more efficient and targeted therapies.

Related information

Keywords

Melanoma, therapeutic targets, interferon regulatory factor 4
Record Number: 175037 / Last updated on: 2016-04-26
Domain: Biology, Medicine