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A novel endoscope for tissue dysplasia

An endoscope capable of delivering state-of-the-art image modalities in the clinic would be an enormous diagnostic asset.
A novel endoscope for tissue dysplasia
Epithelial dysplasia is a pre-cancerous state with a high probability of transition to carcinoma and invasive cancer. Prompt diagnosis of dysplasia may allow faster interventions and improve patient outcome.

Traditionally, dysplasia diagnosis occurs by pathological examination of a biopsy. However, the focal nature of the dysplastic abnormalities often escapes diagnosis, thereby necessitating the development of non-invasive methods capable of surveying large area tissue.

With this in mind, researchers on the EU-funded SCOPE (Spectroscopy Combined with Optical Polarization for Endoscopy) initiative proposed to develop a flexible endoscope with a multispectral imaging system. This would enable the detection of tissue chromophores such as oxy and deoxy haemoglobin. The spatial distribution of these molecules would translate into specific haemodynamic and metabolic tissue properties.

The consortium tested their prototype during uterine transplant operations in big animal models. Their contrast enhancement method of reflectance spectroscopy successfully allowed scientists to image organ oxygenation and obtain physiological parameters such as heart beat rate and breathing rate. Further device optimisation led to faster image acquisition and more accurate detection.

Plans include the development of the instrumentation to provide information on tissue morphology, biochemistry and oxygenation. This instrument has the capacity to perform under minimally invasive conditions and discriminate healthy from diseased tissues with great accuracy. This renders it an important clinical tool for the diagnosis of cardiovascular diseases, cancer, as well as for monitoring the viability of transplant organs.

Related information


Endoscope, dysplasia, cancer, imaging, spectroscopy, diagnosis
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