Wspólnotowy Serwis Informacyjny Badan i Rozwoju - CORDIS

Periodic Report Summary 2 - BASTION (From Basic to Translational Research in Oncology)

Project Context and Objectives:
The BASTION project is envisioned to allow Medical University of Warsaw (MUW) to become a leading research and clinical oncology center in Central Europe. Based on core ensemble of internationally recognized research groups and lead scientists BASTION aims to strengthen MUW’s research potential in basic and translational oncology via five operating objectives:
- initiating and consolidating cooperation between 9 MUW research teams and 11 partnering organizations from leading European research labs and 2 innovation driven SMEs via secondments;
- fostering exchange of scientific ideas and know-how by organizing 5 workshops focused on molecular oncology and one international conference;
- establishing a bioinformatics group focused on personalized medicine and recruiting 12 experienced researchers, 2 IT specialists and 3 professional managers;
- building research capacity by acquiring 7 modern research equipment items;
- creating a pro-innovative environment supporting exploitation and dissemination of BASTION research to raise awareness of basic and translational oncology.
BASTION is also envisioned to become a top quality experimental oncology platform incorporating novel research techniques to improve the understanding of carcinogenesis and tumor progression leading to development of new therapeutic and diagnostic tools. This can only be achieved through broad and active networking with top research centers in Europe.
Work Package (WP) 1 included exchange of know-how and best practice through twinning between MUW researchers and laboratories from partnering organizations. A major goal of those bilateral visits was to bring together a highly skilled and complementary assembly of European researchers from academic and clinical centers and researchers from MUW participating in BASTION. 52 outgoing and 15 incoming visits accomplished provided practical training in new technologies and allowed new collaborations and new research projects undertaken.
WP2 included organization of 5 workshop on (i) cancer genetics, (ii) application of flow cytometry in molecular oncology, (iii) techniques in analysis of cancer vasculature, (iv) genome-wide methods in cancer genetics”, (v) molecular diagnostics in cancer. An international conference “Translational Research in Oncology in New Member State Economies – TRON” was organized. A number of initiatives were developed to disseminate the health and medical knowledge to the professionals and the general public, including: establishing cooperation with the crucial patient advocacy groups, gaining official patronage form the Ministries, establishing cooperation with media and gain their support, development of promotional materials, lunching of the BASTION web site.
WP3 BASTION project has fully used its opportunity to recruit a leader of the bioinformatics group and twelve 11 postdoctoral top-level qualified researchers with high ability to increase research potential in basic and translational oncology at MUW. Moreover two IT specialist have been employed to facilitate development and use of bioinformatics tools. The three 3 professional managers employed within the BASTION include a project manager, an innovation manager and PR specialists (part-time) to improve and professionalize project management, facilitate and increase the impact of translational studies in oncology to promote innovation-driven translational research as well as to develop tools and disseminate results of the BASTION, respectively.
WP4 involved the purchase of research equipment to fill a significant gap in the research armamentarium of BASTION teams, including 6 items of modern research equipment and bioinformatics infrastructure and support for personalized medicine studies.
WP5 involved implementing efficient IP protection and innovation management schemes, and organizing joint events with commercial and academic partners to transfer best-practice in science-industry cooperation and promote innovation driven translational research.

Project Results:
General objectives of the BASTION project for the reporting period were:
- better integration in European Research Area,
- improvement in the quality of research,
- increased contribution to sustainable regional development
- building the capacity of improved success rate in application for European research cooperation programmes
BASTION aimed to overcome existing shortcomings by strengthening research potential of the Medical University of Warsaw (MUW) in basic and translational oncology. This goal was achieved by execution of seven specific project operating objectives:
• increasing scientific dialogue between MUW, European academic research centers and innovation driven SMEs via secondments of scientific and innovation management staff to transfer knowledge, new research methodologies and techniques, discussions on research progress, share experimental data, work on joint research proposals, publish in top scientific journals;
• facilitating the exchange of scientific ideas, share research results and engage in new collaborations, as well as to increase the impact of translational studies in oncology by knowledge sharing and implementing targeted dissemination actions involving all relevant stakeholders at the regional, national and European levels by organizing thematic workshop; supporting attendance at international conferences and training workshops; engaging key stakeholders and decision makers in BASTION from the very beginning of the project; educating the public on the benefits of translational research for public health;
• build human potential by recruiting 12 researchers with international experience in basic and clinical oncology (one new research group leader and 11 post-docs) with particular emphasis on scientists and professionals returning from abroad, as well as two IT professionals with background in bioinformatics to accelerate the establishment of an independent bioinformatics research group;
• build the capacity of MUW’s research base in molecular oncology and translational studies by purchasing state-of-the art equipment items,
• facilitating and increasing the impact of translational studies in oncology by: hiring a professional innovation manager, implementing efficient IP protection and innovation management schemes, organizing joint events with Science Business as well as the research / academic partners to transfer best-practice in science – industry cooperation and promote innovation driven translational research;
• improving, updating and professionalizing project management processes at MUW by hiring an experienced project manager, at the same time assuring smooth and efficient execution of the project and timely delivery of all envisioned project results.

Potential Impact:
The BASTION project has fully used its opportunity to recruit twelve top-level qualified researchers with high ability to increase research potential in basic and translational oncology at Medical University of Warsaw (WP3). The technological expertise and scientific background of all recruits fits BASTION effort to strengthen the existing areas of excellence in oncology research. Moreover, each individual has brought in know-how and experience in translational oncology work, helped to bridge the gaps and created links among research groups working at MUW. All leaders have succeeded in recruiting extremely diligent and hardworking postdocs showing a great enthusiasm for their work in the field of experimental oncology. We are completely sure that newly employed researchers have strongly contributed to the success of BASTION project. All BASTION researchers were eligible for applying for additional funding for their research activities. Moreover, team leaders supported newly employed researchers with their grant funding. The majority of hired researchers has applied for funding and fully used their opportunities by acquiring 50 research grants from funding agencies to support their further research activities and help them to develop their research carriers. Additionally, a qualified lab leader of bioinformatics unit with high ability to increase research potential in basic and translational oncology has been employed. Lab leader has already brought a technological expertise which allows MUW to engage into new research direction through collaborative efforts. He has already managed to initiate several collaborations with teams located both in and outside MUW. His newly recruited team included two postdoctoral fellows and two IT specialists. The team provided a number of comprehensive and versatile biotechnological approaches to the tasks delineated under the BASTION program.
The equipment purchased within WP4 has been extensively used in all other WPs and forms the basis for collaborative initiatives of the BASTION research teams for the future. It is important to emphasize the complementarity of the purchased equipment. The automated nucleic acid extractor together with laser microdissection platform provide the means of acquisition of DNA/RNA, i.e. substances which are the main carriers of information in each cell and therefore represent subject of analyses in virtually every field of biological research. The machines complement each other as the former one can be used for majority of macroscopic samples whereas the latter is dedicated for extractions at the microscopic scale (even from single cells). The Fluidigm platform together with the DNA sequencer provide the means to carry out sophisticated analyses of DNA/RNA isolated with the first two machines. In particular the Fluidigm platform allows to efficiently prepare middle scale libraries from isolated nucleic acids whereas the DNA sequencer complements the previously acquired low throughput machine allowing to sequence those libraries. The results obtained with the nucleic acid sequencing techniques can be next verified on the protein level with the use of the protein purification work station. The ability to express and obtain highly purified recombinant proteins creates the unique opportunity to study the detailed function and interactions of previously determined gene products. Moreover, acquisition of the pipetting biorobot and multispectral plate reader allows for further evaluation of the target gene(s) function in numerous cell-based in vitro assays implementing e.g. absorbance, luminescence, fluorescence and/or singlet oxygen transfer measurements. Thus, the abovementioned pieces of equipment allow to carry out a streamlined comprehensive pipeline of experiments consisting of purifying, analyzing nucleic acids and verify the role of their protein products in vitro which is expected to useful both within BASTION and by MUW’s researchers.

List of Websites:


Iwona Drozdowska-Rusinowicz, (Vice Head of Projects Office)
Tel.: +48 22 57 20 461
Faks: +48 22 599 21 94
Adres e-mail
Numer rekordu: 182609 / Ostatnia aktualizacja: 2016-05-18
Źródło informacji: SESAM