Forschungs- & Entwicklungsinformationsdienst der Gemeinschaft - CORDIS

ERC

RECONTEXT Berichtzusammenfassung

Project ID: 261177
Gefördert unter: FP7-IDEAS-ERC
Land: Netherlands

Final Report Summary - RECONTEXT (From neurons to behaviour: Context representation and memory reconsolidation in the entorhinal hippocampal system)

In this project, we have been instrumental in translating neural coding mechanisms underlying wayfinding from Nobel-prize awarded rodent electrophysiology to the systems level in humans to examine brain processes supporting spatial navigation and remembering. By combining functional neuroimaging with virtual-reality, we have identified neural mechanisms of spatial mapping which provide a neural context signal for the formation and consolidation of episodic memories and its breakdown in a model of Alzheimer’s disease. We have further shown that memories are not stored in isolation but are rather represented in hierarchical networks within a neural memory space and demonstrated how spatial coding principles provide the key neural mechanisms that enable multiple memories to become organised and consolidated in mnemonic networks for successful decision making.

Kontakt

Petra ten Have
Tel.: +31 24 36 10751
Fax: +31 24 36 10652
E-Mail-Adresse
Datensatznummer: 184789 / Zuletzt geändert am: 2016-06-27