Service Communautaire d'Information sur la Recherche et le Développement - CORDIS


RECONTEXT Résumé de rapport

Project ID: 261177
Financé au titre de: FP7-IDEAS-ERC
Pays: Netherlands

Final Report Summary - RECONTEXT (From neurons to behaviour: Context representation and memory reconsolidation in the entorhinal hippocampal system)

In this project, we have been instrumental in translating neural coding mechanisms underlying wayfinding from Nobel-prize awarded rodent electrophysiology to the systems level in humans to examine brain processes supporting spatial navigation and remembering. By combining functional neuroimaging with virtual-reality, we have identified neural mechanisms of spatial mapping which provide a neural context signal for the formation and consolidation of episodic memories and its breakdown in a model of Alzheimer’s disease. We have further shown that memories are not stored in isolation but are rather represented in hierarchical networks within a neural memory space and demonstrated how spatial coding principles provide the key neural mechanisms that enable multiple memories to become organised and consolidated in mnemonic networks for successful decision making.


Petra ten Have
Tél.: +31 24 36 10751
Fax: +31 24 36 10652
Numéro d'enregistrement: 184789 / Dernière mise à jour le: 2016-06-27