Community Research and Development Information Service - CORDIS

Periodic Report Summary 1 - IMAGINGREDOX (Molecular imaging of redox processes in cancer)

Summary description of project objectives
The broad mission of the VISIONLab (www.bohndieklab.org) is to devise new imaging approaches to address unanswered questions about the role of oxygen in cancer. We achieve developments in this area through a combination of: modelling, to understand the interactions between light and tissue; and innovative instrument design, integrating new technologies to enable spectral imaging. The overall aims of our research programme, representing expanded versions of those articulated in the original fellowship proposal, are:
• To develop and translate clinically relevant approaches for imaging oxidative and hypoxic stresses in cancer for:
o Tumour staging
o Therapeutic monitoring
• To advance our understanding of the relationship between oxidative and hypoxic stresses in cancer, as related to:
o The emergence of the disease from sites of chronic inflammation
o The development of drug resistance in advanced disease
• To create novel imaging techniques that facilitate early detection of cancers in the gastrointestinal tract and lung, arising from sites of chronic inflammation or carcinogen exposure.

Description of work performed so far
• Establishing key equipment to perform optical characterization of tissue, near infrared endoscopy, in vivo optoacoustic imaging, in vitro Raman spectroscopy and hyperspectral imaging
• Technical validation of above imaging techniques, pertaining to precision and accuracy
• Initial biological validation of above imaging techniques in models of cancer both in vitro and in vivo
• Produced 8 manuscripts (3 in revision, 5 in submission) and presented over 30 invited talks

Expected final results and potential impact
By applying such developments to preclinical disease models, and ultimately in patients, we aim to better understand the role of oxygen and related stresses in cancer progression, from early development through to treatment resistance. This could lead to increased early disease detection and improved cancer patient management.

Reported by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom

Subjects

Life Sciences
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