Community Research and Development Information Service - CORDIS

FP7

Neuro-penta Report Summary

Project reference: 631416
Funded under: FP7-PEOPLE

Periodic Report Summary 1 - NEURO-PENTA (Structure of the brain serotonine 5-HT3 receptor and other mammalian Cys-loop receptors)

Our team aims to better understand how membrane machines operate at the molecular scale, using structural biology. We mainly work with ion channels, and especially with pentameric neurotransmitter-gated channels. Research projects mix state-of-the-art eukaryotic expression systems, solid biochemistry, biophysical characterization with two structural methods: X-ray crystallography and single particle cryo-EM.

Our research is curiosity-driven, but focuses on membrane proteins that play crucial roles in health and disease. For example, current projects are related to nausea, depression and infertility.

In the framework of the Marie Curie CIG project we develop tools to facilitate structural studies of pentameric neurotransmitter-gated receptors and use them to try and solve structures. During the first two years of the project and of the lab, we have established good basis for protein expression and we have promising results -at the biochemical level- with three receptors.

Contact

ROCHET, Guillaume (Responsable Service Partenariat et Valorisation)
Tel.: +33 4 76881005
Fax: +33 4 76881174
E-mail

Subjects

Life Sciences
Record Number: 187597 / Last updated on: 2016-08-22