Community Research and Development Information Service - CORDIS

FP7

STROFUNSCAFF Report Summary

Project reference: 306873
Funded under: FP7-IDEAS-ERC

Mid-Term Report Summary - STROFUNSCAFF (Strong, functional, tunable, self-assembling hydrogel scaffolds for regenerative medicine)

TThe aim of STROFUNSCAFF is to develop a novel material and fabrication platforms to generate strong, tunable, and highly biomimetic nanofibrous hydrogel scaffolds with an unparalleled signaling level as well as control over its properties in both space and time. The project is based on the opportunities to integrate self-assembling peptides with proteins (elastin-like proteins) to create materials that overcome major current critical limitations of self-assembling materials and combines strength, tunability, and bioactivity. Furthermore, the work aims to develop novel fabrication methods capable of generating unique biomimetic environments for both in vitro and in vivo applications. The project has led to the development of new materials and material fabrication platforms that include a dynamic material (Inostroza-Brito et al., Nature Chemistry 2015), a material capable of controlling mineralization and mineralize tissue regeneration (Tejeda-Montes et al., Biomaterials 2014, Elsherkawy et al., Materials Today, accepted for publication), and a novel 3D printing technique to create molecular patterns within 3D hydrogels (S/N 300056349, A/N EP12382102.7). The project has generated high impact results (Nature Chemistry, Biomaterials), numerous media coverage and various media appearances (i.e. http://www.forces.tv/18689077, http://www.rsc.org/chemistryworld/2015/09/self-assembly-healing-protein-scaffold-cell-growth, https://www.facebook.com/NowThisNews/videos/919977778092347/,
http://www.qmul.ac.uk/media/news/items/se/134686.html), invited presentations at international conferences (i.e. keynote lecture at TERMIS 2016) and leading international institutes (i.e. Wyss Institute, May 2016, Wake Forest Institute for Regenerative Medicine, May 2016), and collaborations nationally and internationally.

Contact

DOW, Greg
Tel.: +44 0 20 7882 2569
Fax: +44 0 20 7882 7276
E-mail
Record Number: 187722 / Last updated on: 2016-08-23