Community Research and Development Information Service - CORDIS

FP7

EUROMBR Report Summary

Project ID: 608104
Funded under: FP7-PEOPLE
Country: Denmark

Periodic Report Summary 1 - EUROMBR (European network for innovative microbioreactor applications in bioprocess development)

EUROMBR is a project that runs from November 2013 until October 2017. The project creates a platform of mobility and training of young researchers, both for PhD students and post-docs. The project is organized in customized research projects, exchanges knowhow among researchers and partners and gives the opportunity to attend at dedicated workshops and seminars, as well as in training in research based complementary skills (project management, team leadership, intellectual property rights, etc).

The main objective of the EUROMBR project is to deliver a trans-European network of industrially oriented specialists fully trained in the development and application of microbioreactor (MBR) technology to support the progress of innovative bio-based manufacturing processes.

In practice, development of these bio-based manufacturing processes is very expensive and requires tremendous amounts of experimental effort:

1. During screening for new processes or applications a large number of small-scale experiments are required to identify the most suitable candidates.

2. When scaling up a process via lab to pilot to production scale, many time-consuming and expensive experiments are necessary to determine those conditions that yield the best process performance.

In the current state-of-the-art bio-based manufacturing processes biocatalysis is increasingly applied to the production of bulk chemicals, fine chemicals, pharmaceuticals and agrochemicals. This project aims at further promoting the use of microbioreactors (MBRs) for more efficient screening and evaluation of biocatalytic and fermentation processes. MBRs are a promising tool due to their low production cost, small working volumes, flexibility and their potential for information-rich experiments under well-controlled experimental conditions.

In the EUROMBR project, we will further develop MBRs for chemical and biochemical screening, paying special attention to MBR parallelization and applicability for different applications. In addition, characterization of experimental uncertainty, development of reactant feeding strategies at micro-scale and coupling of microscale experimentation to automated design of experiments (DoE) will document applicability of MBRs for chemical and biochemical research. To enhance the applicability of microfluidic enzymatic reactors for organic synthesis, we will establish microfluidic chemo-biocatalytic reaction systems that enable rapid characterization of biosynthetic pathways and chemo-enzymatic conversions. This will be underpinned with immobilization methods that permit rapid and reversible binding of a range of biocatalysts and modelling that relates the kinetic data with results from larger scales. Complemented with precisely positioned fluorescence-based sensor arrays, novel nanosensor particle concepts, and integrated Raman and NIR probes, the MBRs will deliver the data rich experimentation needed for industrial applications. Data processing and information management will be accomplished by developing Computation Fluid Dynamics (CFD) and mathematical modelling methods that permit prediction and interpretation of fermentation and biocatalytic processes in MBRs.

Contact

Ulrich Krühne, (Associate Professor)
Tel.: +45 45252960
E-mail

Subjects

Life Sciences
Record Number: 188895 / Last updated on: 2016-09-16