Mid-Term Report Summary - CARDIOREDOX (Redox sensing and signalling in cardiovascular health and disease)
The aims of this project include the characterization of thiol-based protein redox sensors in the cardiovascular system, including some that we already identified and some that yet unknown (novel). The novel redox sensors are to be identified as part of this study using proteomics, and the follow-up studies on these proteins is aimed at understanding the mechanism of their regulation and the potential consequence for cardiovascular health and disease. We have made significant progress in this “CARDIOREDOX” project, and published some significant new findings relating to the aims of this work outlined above. Furthermore, several projects are quite well advanced and should be submitted for publication in the next 12 months. On top of this we are actively performing redox proteomics studies, which have identified a great many candidate redox-regulated protein – some of which we will aim to study in more detail over the remaining duration of this project. Overall, significant progress has been made, with the project already generating published new knowledge, with a lot more outputs anticipated in the next two years or so.
Paul Labbett, (Director of Research Grants and Contracts Division)
Record Number: 189103 / Last updated on: 2016-09-20