Community Research and Development Information Service - CORDIS

FP7

MOODFOOD Report Summary

Project ID: 613598
Funded under: FP7-KBBE
Country: Netherlands

Periodic Report Summary 2 - MOODFOOD (Multi-country cOllaborative project on the rOle of Diet, FOod-related behaviour, and Obesity in the prevention of Depression (MooDFOOD))

Project Context and Objectives:
MooDFOOD: Multi-country cOllaborative project on the rOle of Diet, Food-related behaviour, and Obesity in the prevention of Depression.

Depression is one of the most prevalent and disabling disorders in the EU and it places a heavy burden on individuals and their families. A large proportion of the EU population is overweight which increases depression risk. Improvement of food-related behaviour and nutrient status may prevent depression, specifically for people prone to being overweight. Unravelling the different pathways that link nutritional behaviour to the development of depression and identifying potential psychological, lifestyle, and environmental mechanisms is exactly at the centre of the MooDFOOD project. MooDFOOD is one of the largest consortia investigating depression and the first to address how food intake, nutrient status, food-related behaviour and obesity are linked to the development of depression.

The MooDFOOD consortium combines expertise in nutrition, consumer behaviour, psychiatry and preventive psychology. MooDFOOD employs an unique approach where high quality data from longitudinal prospective European cohort studies will be combined with new data from surveys, short-term experiments and a multi-centre long-term preventive intervention study to unravel these multifaceted links of food intake, nutrient status, food-related behaviour and obesity with depression. The obtained scientific evidence will be integrated with information from stakeholders regarding future implementation as well as information regarding demographic trends, sustainability and planned policy measures will allow the development of innovative nutritional strategies for the prevention of depression and contribute to the overall health of EU-citizens.

To finally understand how food intake, nutrient status, food-related behaviour and obesity are linked to the development of depression. MooDFOOD will pursue the following two objectives:
1. To gain a better understanding of the psychological, lifestyle and environmental pathways underlying the multi-faceted, bidirectional links of food intake,nutrient status, food-related behaviour and obesity with depression.
a. To gain a better understanding of the bidirectional links of food intake, nutrient status, food-related behaviour and obesity with depression.
b. To determine the underlying lifestyle, environmental and psychological pathways of these links.

2. To develop innovative evidence-based, feasible, effective and sustainable nutritional strategies for the prevention of depression in EU citizens.
a. To establish the feasibility and effectiveness of nutritional strategies on the prevention of depression.
b. To develop optimal, sustainable, and evidence-based nutritional strategies for the prevention of depression.
c. To provide and promote guidelines and practical tools for stakeholders which will improve implementation and thus contribute to nutrition-related prevention of depression.

Project Results:
WP1 focusses on the collection of observational evidence for the bidirectional relation between food intake, nutrient status and obesity with (change in) depression. In WP2 we investigate the link between diet and depressive symptoms by determining the role of food-related behaviours from survey data and future experiments. The main purpose of WP3 is the preparation and execution of the multi-country randomized controlled prevention trial to test different nutritional strategies for the prevention of depression in 4 trial sites. All locally collected prevention trial data are aggregated and integrated in a database by WP4. All the scientific knowledge obtained in the project (WP1-4) will be directly communicated between partners and work packages by WP5. The tasks of WP6 centre around the implementation of the project’s dissemination and communications plan and WP7 is monitoring the central project management. WP1 The scientific results of WP1 suggest that specific dietary patterns (i.e. Tuscan diet, DASH diet) are inversely associated with depressive symptoms over time. High intake of certain sugar and fat are associated with more depressive symptoms. Low vitamin D and low n-3 fatty acids status appear to be associated with increased risk of major depressive disorder. Furthermore, the first results show that obesity predisposes to clinical depression, and that depression leads to either weight loss or weight gain, with no major impact of antidepressants on weight change. WP2 By conducting surveys and by adding food-related behaviour data to existing cohort studies this WP investigates the link between diet and depressive symptoms by determining the role of food-related behaviours. Preliminary results indicate that higher mindful eating was associated with lower depressive symptoms and this link was mediated by psychological eating styles, emotional eating mediates the link between depressive symptoms and obesity and that a pattern with irregular meals was associated with lower diet quality indicator, higher depressive symptoms, but not higher BMI. WP3 The main purpose of WP3 is the execution of the multi-country randomized controlled prevention trial to test two different nutritional strategies for the prevention of depression in 4 trial sites. Standardized protocols have been developed, effective local recruitment strategies were implemented, storage and distribution of supplements was arranged and staff training took place before commencing the trial in July 2015 in Leipzig and in September 2015 in Mallorca, Exeter and Amsterdam. The trial is still ongoing, but all interim status reports show sufficient progress and with extension of recruitment for three months we are still aiming for 1000 participants. WP4 A database with a web-based infrastructure was developed with central applications for entering and ultimately aggregating and integrating all nationally collected primary and secondary outcome data to ensure efficient data storage, cleaning and documentation. WP4 provides all sites with weekly updates on the collected data to monitor the rate of inclusion and the effectiveness of recruitment strategies. WP5 All the scientific knowledge obtained in the project will be directly communicated between partners and work packages. With their collaborative approach WP5 monitors inter WP alignment, obtains and translates scientific knowledge, and communicates scientific information towards relevant scientific communities, opinion leaders and the general public. WP6 The project has an ambitious dissemination component governed by a clear, action driven plan. A collaborative approach is used to disseminate project results and actions, with all partners involved in developing strategies and undertaking actions. WP7 The main task for WP7 is monitoring the central project management.The MooDFOOD project has achieved most of its objectives with relatively minor deviations.
Potential Impact:
The MooDFOOD project will result in fundamental insights into the mechanisms behind nutrition and the development of depression. We will deliver scientific output based on a unique combination of six cohort studies and based on a series of short experiments as well as a multi-country prevention trial establishing the causality of the link between food and depression. MooDFOOD will deliver:
- Elucidation of the impact of food intake, nutrient status, food-related behaviour, and obesity on the prevention of depression
- Identification of the impact of depression on food intake, nutrient status, food-related behaviour and obesity
- Insight into psychological, lifestyle, and environmental pathways underlying the bi-directional link of food intake, nutrient status, food-related behaviour and obesity with depression
- Identification of which modifications in food-related behaviours and nutrient status related to depression may lead to beneficial dietary changes and a lower environmental burden of the diet
- Important insight into the causality of the observed associations and underlying pathways

This knowledge on causal relationships will finally enable the development of feasible, effective and sustainable nutritional strategies for the prevention of depression and the translation of these strategies to practical tools with active input from relevant stakeholders. MooDFOOD will translate these nutritional strategies into evidence-based practical tools and guidelines related to the prevention of depression by nutrition. The results of MooDFOOD will be delivered as scientific publications, web based applications and different sorts of classical and non-classical dissemination materials that are specifically tailored to different interest groups and stakeholders. All our dissemination materials will be evidence-based on the results of MooDFOOD and other European and national projects and will provide advice, suggestions and reference to best practices. Examples:
- Treatment guidelines and practical tools for health professionals targeting food intake and food-related behaviour for the prevention of depression symptoms in non-depressed and depressed consumers
- Evidence-based nutritional guidelines for EU citizens including the whole diet as well as nutrient supplement use and dietary behaviour
- Food product development recommendations and scientific evidence supporting health claims for the food industry
- Policy advice and recommendations to promote healthy eating and prevent depression for individual Member States and the EU

Promoting these guidelines and practical tools through extensive European networks, MooDFOOD will in the long run contribute importantly towards improving the diet of all EU citizens in a sustainable way and towards preventing the third leading contributor to the global disease burden, with enormous emotional, physical, economic and social benefits.

List of Websites:
www.moodfood-vu.eu

Contact

Yvonne Kops, (Managing director FALW)
Tel.: +31 20 5987304
Fax: +31 20 5989950
E-mail
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top