Community Research and Development Information Service - CORDIS


BIOCURE Report Summary

Project ID: 712445

Periodic Reporting for period 1 - BIOCURE (Novel Biomaterial for Improved and Cost-efficient Wound Healing)

Reporting period: 2016-02-01 to 2016-07-31

Summary of the context and overall objectives of the project

Wound treatment is a major healthcare cost for all developed countries. In the UK for example, it is estimated that up to 4% of all health care costs are due to wounds . The global market for advanced wound care products was projected to be $ 3 billion in 2012, with an annual growth above 10% and representing one of the leading medical product sectors . However, this represents only some 15-20% of the overall cost of wound treatment, where hospitalisation and nurse time represent the remaining costs. The main driver for growth is the treatment of chronic and complex wounds in an aging population, complicated by the increase in diabetes and other metabolic disorders. Ideally, wounds at-risk of becoming chronic in high-risk patients should be treated from the outset with the most effective products (such as collagen based dressings), however, due to cost considerations, this is not the case.

The direct and societal cost in the treatment of delayed and chronic wounds is a significant problem in all major developed countries. Efficiency in wound healing is now a critical element in the struggle to maintain service levels in face of an aging population with its increased level of complex illnesses such as diabetes and venous insufficiency both of which lead to chronic leg wounds and ulcers. At the same time the National Health Service budget assumption is for zero budget growth between 2015 and 2020 in real terms. The conflicting trends in the UK are typical of that of all EU countries. Clearly, costs must be reduced per patient in this scenario. In most socialized medicine countries, presently most pressure is applied to driving down consumable costs.

Wound healing products have remained largely unchanged for the last 20 years. Recently, enhanced products based on bovine collagen or porcine materials have shown to be more effective than the traditional dressings based on natural materials such as cellulose and cotton. Collagen products today have limited use as they are seen as expensive (up to 10 times as expensive as non-collagen products ). In 2011, total collagen product sales worldwide were only USD$91 m even though have increased significantly afterwards. Supply and safety of mammalian derived materials have also limited the usage of such products. In this scenario, effective wound care products, such as collagen based dressings, but with a significantly lower cost, become an attractive solution.
The concept behind BIOCURE – the only EggShell Membrane (ESM) based wound dressing - directly addresses the healthcare industry needs by providing a novel wound care product that it as effective as the existing collagen based dressings, but it is also:
- significantly lower in cost (at least 3 fold lower cost)
- much more easily scalable,
- significantly safer
The combination of product scalability, effectiveness and cost represent a breakthrough in the wound healing market. This will allow for the first time an advanced product to be become the standard of care, reducing both product cost and nursing time. BIOCURE will initially target the two major wound categories with substantial unmet medical need, namely diabetic foot ulcers (DFU) and venous Leg ulcers (VLU).
With BIOCURE, BIOVOTEC and Finesse Medical will, therefore, be in a privileged position to seize a major market opportunity within the healthcare sector.

BIOCURE aims at developing a cost-effective wound dressing based on a novel biomaterial derived from eggshell membrane to be used as first-line treatment in all wounds at risk of delayed or non-healing, reducing the incidence of chronic wounds, such as venous and diabetic ulcers.

Work performed from the beginning of the project to the end of the period covered by the report and main results achieved so far

BIOVOTEC has recently developed a new process which allows the large scale production of a collagen-like biomaterial from eggshell membrane, a by-product of industrial egg production.
This process is manufacturing under GMP conditions a medical device for chronic wounds.
We have so far achieved all steps required to produce the ESM film under GMP conditions as well as production up scaling and we are now starting the pre-clinical safety tests in order to meet the EU regulatory requirements. This will also allow BIOVOTEC to start its clinical trial which is scheduled for 2017.
BIOVOTEC does not want to report its development progress in details as the information still is confidential.
BIOVOTEC has participated in one of the world wide known conference on wound healing in the US and has presented a Poster with excellent feedback and encourage BIOVOTEC to continue.

Progress beyond the state of the art and expected potential impact (including the socio-economic impact and the wider societal implications of the project so far)

The Biocure project is expected to have several impacts which are divided into 3:

Environmental impact:
BIOCURE is now converting eggshell residues – namely, the eggshell membrane – into a commercially valuable by-product – a biomaterial and novel wound healing solution. The waste valorization will have a significant impact in the egg processing industry by reducing the costs with waste disposal and minimizing associated environmental problems. Finally, the BIOVOTEC process is based mainly on mechanical and heat energy and does not create significant chemical residues unlike the current animal collagen extraction industry.

Economical impact:
BIOCURE will positively impact the hospital through reduced treatment costs per wound.

Health Impact:
The patients and clinicians through early stage treatment or resolution of chronic wounds more effectively.

Related information

Record Number: 193062 / Last updated on: 2016-12-16
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