Community Research and Development Information Service - CORDIS

ERC

INCA Report Summary

Project ID: 341009
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Mid-Term Report Summary - INCA (Genetic and environmental factors that control inflammation-driven colon cancer)

In this project we are investigating genetic and immune-mediated control of susceptibility to colitis associated cancer. We use physiologically relevant models of bacteria-driven invasive colon cancer in a multi-disciplinary approach to probe the interaction between genetics, microbial drivers and inflammatory pathways that promote colon cancer. We have identified a gene that controls the innate inflammatory response and shown that deficiencies in this gene promote IFN-gamma mediated intestinal inflammation. Metagenomic and metatranscriptomic analyses of the microbiota have shown changes in oxidative stress pathways in the microbiota during intestinal inflammation, including an association between colitis and multiple pathways implicated in adaptations of commensals to host defence responses, including antimicrobial peptide (AMP) production. We have also identified a novel synergy between IL-22 and a key oncogenic driving mutation in human colorectal cancer. Future studies will probe functional interactions between oncogenic mutations and IL-22 signaling and may identify novel therapeutic pathways in subsets of colorectal cancer patients.

Contact

Gill Wells, (Head of European Team)
Tel.: +44 1865 289800
Fax: +44 1865 289801
E-mail
Record Number: 193241 / Last updated on: 2017-01-17
Follow us on: RSS Facebook Twitter YouTube Managed by the EU Publications Office Top