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ERC

editCRC Report Summary

Project ID: 340176
Funded under: FP7-IDEAS-ERC
Country: Spain

Mid-Term Report Summary - EDITCRC (A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers)

A hallmark of cancer is tumor cell heterogeneity. We discovered that most human colorectal cancers (CRCs) are composed of mixtures of phenotypically distinct tumor cells organized into a stem cell hierarchy that displays a striking resemblance to the healthy colonic epithelium. This project intends to answer fundamental questions about tumour cell heterogeneity and specifically about colorectal cancer stem cells (CRC-SCs) including: Are CRC-SCs the only tumour cell population with long term regenerating potential? Will tumour cell plasticity contribute to the regeneration of the CRC-SC pool after therapy? How do common genetic alterations in CRC influence the CRC hierarchy? Do they affect the stem cell phenotype? To answer these questions we have established a collection of patient derived tumours in vitro in the form of 3D structures called organoids and develop genetic strategies using CRISPR/Cas9 technology to track the behavior of CRC-SCs in human cancer. We anticipate that results from this project may help improved therapeutic treatment of CRC patients.

Reported by

FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain
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