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InanoMOF Report Summary

Project ID: 615954
Funded under: FP7-IDEAS-ERC
Country: Spain

Mid-Term Report Summary - INANOMOF (Multifunctional micro- and nanostructures assembled from nanoscale metal-organic frameworks and inorganic nanoparticles)

In InanoMOF project, we have developed several frontier supramolecular and nanochemistry-based methodologies for the synthesis of new systems via controlled assembly of nanoscale porous Metal-Organic Frameworks (nanoMOFs) and functional inorganic nanoparticles (INPs). The resulting nanoMOF@INP systems mix both type of nanomaterials and therefore, they marry the unique properties of INPs (e.g. Au, iron oxide, Pt, Pd, CeO/Cu, Fe(0), and hollow Pt, Pd and Au NPs, etc.) with the functional porosity of MOFs (ZIF-8, UiO-66, UiO-66-SH, etc.). Some of these developed methods include the nanostructure template synthesis, the desymmetrization at interfaces and the supramolecular-directed assembly, from which a rich variety of nanoMOF@INPs have been synthesized. From these syntheses, two main classes of discrete nano-objects have been designed: (i) objects that are made by coupling the INPs on the surface of the MOF particles; and (ii) objects in which the INPs are encapsulated inside the MOF particles. Remarkably, the complexity of the latter nano-objects has been improved with the design of onion-like systems in which alternate layers of MOFs and INPs are grown. Following this approach, nanoMOF@INP systems containing more than one type of functional INPs, such as Au and Pd NPs, can be synthesized. On the other hand, another method based on the spray-drying technology has been developed to achieve the synthesis of higher-level nanoMOF@INP superstructures or beads. This new method, which has been patented and licensed to a European SME, is based on introducing a continuous-flow reactor at the entrance of the spray dryer. The whole continuous process enables the collection of dried MOF particles shaped in the form of microspherical superstructures or beads that incorporate the INPs inside their matrices.

Once synthesized, the physicochemical properties of nanoMOF@INP systems have been studied, certifying in all cases that the inherent porosity of MOFs as well as the functions (e.g. magnetism, optics, etc.) of the INPs are maintained. Moreover, we have made the first steps to ascertain the use of these nanoMOF@INPs as drug-delivery systems, pollutant removal systems and catalysts. In the first application, the successful encapsulation of anticancer drugs such as doxorubicin and cisplatin has been confirmed, achieving maximum encapsulation rates of, for example, 0.2 gram of doxorubicin per gram of nanoZIF-8@hollowAuNP composite. In the other applications, a composite made of nanoUiO-66-SH and Co has shown to be efficient for extracting mercury from water since it can sequester 99% of 10 ppm of mercury from water in 30 min and then be easily removed using a magnet. Moreover, other composites built up from nanoZIF-8 and hollow PdNPs or PtNPs have shown to be very efficient for the catalytic reduction of 4-nitrophenol, a water pollutant with high toxicity.

Contact

Marta Gonzalez Gomez, (Project Manager)
Tel.: +34 93 737 4635
E-mail
Record Number: 193263 / Last updated on: 2017-01-17
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