Community Research and Development Information Service - CORDIS


MRNA-DECAY Report Summary

Project ID: 616052
Funded under: FP7-IDEAS-ERC
Country: Germany

Mid-Term Report Summary - MRNA-DECAY (NMR Spectroscopy of very large complexes: the atomic details of the mRNA degradation machinery)

The cellular environment is extremely complex and contains thousands of different bio-molecules. It is of fundamental interest to understand how these bio-molecules assemble into a highly organized molecular system. We are especially interested in the cellular pathways that degrade mRNA and would like to understand with atomic resolution how dozens of proteins assemble into a functional molecular machinery. Our data shows that the enzymes that are involved in mRNA degradation are highly dynamic. On one hand they change their shape over time, which regulates their activity. On the other hand, the enzymes and co-factors engage in a highly dynamic network of interactions that determines how these bio-molecules cluster in the cell. Our work thus clearly reveals that molecular machines are much more dynamic than their known static structures suggest.


Antje Lemper-Rupp, (Financial Administrator)
Tel.: +49 7071 601307
Fax: +49 7071 601305
Record Number: 194421 / Last updated on: 2017-02-14
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