Community Research and Development Information Service - CORDIS

ERC

HIGEN Report Summary

Project ID: 617306
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Mid-Term Report Summary - HIGEN (ADVANCED STATISTICAL METHODS FOR HIGH-DIMENSIONAL GENETIC STUDIES)

We have developed statistical methods that allow researchers to take measured genetic data from individuals and separate it into two parts that have been inherited from each parent. It allows researchers to obtain a much more accurate view of an individuals genetic data. This process is known as phasing and is widely used in human genetics research. Our methods are some of the most accurate.

We have formed an international project called the Haplotype Reference Consortium (HRC) (http://www.haplotype-reference-consortium.org/) that has collected together whole genome sequence data from 20 different studies. We combined together this data on >32,000 people to create a haplotype reference panel. Such datasets are widely used in almost all genome-wide association studies, as they allow prediction of missing data, which increases power to make new discoveries and facilitates groups working together to share data.

We are actively working on statistical methods that allow researchers to jointly analyse the multiple trait and disease information collected on study participants. In general this allows a more detailed view of the genetic basis of diseases.

Our research has been published in top journals. In 2016 alone we published 4 methods papers in Nature Genetics.

Reported by

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
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