Community Research and Development Information Service - CORDIS

ERC

BioWater Report Summary

Project ID: 335508
Funded under: FP7-IDEAS-ERC
Country: Ireland

Mid-Term Report Summary - BIOWATER (Development of new chemical imaging techniques to understand the function of water in biocompatibility, biodegradation and biofouling)

BioWater aims to unravel the structure of water at biomaterial interfaces and its relationship to the processes of biodegradation, biocompatibility and biofouling, using chemical imaging (CI), multivariate data analysis (chemometrics), molecular dynamics and conventional methods for biomaterial characterisation. In the first reporting period, the research focused on the development of CI methods to characterise interactions between biomaterials and water. Novel experimental methodologies have been developed and evaluated for a range of biomaterials, including biopolymers, bone cements, hydrogels and coatings in contact with water. Vibrational spectral features related to contact angle measurements have been investigated and the interaction between water and biomaterials has been monitored over time using Near infrared, Mid infrared and Raman CI. Novel chemometric methods have been developed to: correlate CI data with conventional methods for biomaterial characterization, to deal with the large datasets encountered in CI experiments for time series analysis and to enable fusion of CI data from different sources. We have developed theoretical approaches based on molecular dynamics to provide information at the atomic level on structures that water adopts in the interface. All software needed to perform all analysis has been developed entirely within the research group. We will combine the simulation data with experimental methods in the next period.

Reported by

UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
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