Community Research and Development Information Service - CORDIS

Final Report Summary - UCNANOMAT4IPACT (Novel Upconversion Nanomaterials for Inorganic Photoactivated Chemotherapy)

The project has investigated the use of upconverting nanoparticles (UCNPs) as photoactive nanoplatforms for the light-activation of metal-based anticancer prodrugs. The unique optical properties of upconverting materials allow using near-infrared light excitation sources to transform metal-based prodrugs in biologically active species. At such wavelength range, light achieves better tissue penetration and causes less damages to biological tissues. The project has demonstrated that the adopted strategy was successful and Pt and Ru anticancer agents could be photoactivated with 980-nm light.
New synthetic approaches were developed within UCnanomat4iPACT to functionalize the surface of UCNP nanoparticle and carry metal-based prodrugs. In the project, the photochemistry of hybrid UCNP-metal complex nanoconstructs was investigated in solution and physiological-like conditions.
Furthermore, biocompatibility studies performed in our laboratories on UCNP materials functionalized with phosphonates showed that they are suitable for applications in tissues, whereas imaging experiments indicated they are good MRI T1-contrast agents and that UCNPs can be employed as nuclear imaging probes to study biodistribution in vivo.

Albeit results obtained in the project demonstrate UCnanomat4iPACT approach is promising, improvements in the light upconversion efficiency of UCNPs, as well as their design as delivery platforms, must be pursued for application in advanced preclinical settings.
The capacity of employing near infrared light as excitation sources expands the potential of metal-based PACT prodrugs, which rarely can be activated at convenient wavelengths for photochemotherapy.

Project website: https://lucasalassa.wixsite.com/salassa

Contact

Alfonso Egaña, (Chief Financial Officer)
Tel.: +34943005300
Fax: +34943005301
E-mail

Subjects

Life Sciences
Record Number: 197118 / Last updated on: 2017-04-10
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