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PhysProt Report Summary

Project ID: 337969
Funded under: FP7-IDEAS-ERC
Country: United Kingdom

Mid-Term Report Summary - PHYSPROT (Determining Physical Properties of Heterogeneous Protein Complexes in Small Volumes)

The PhysProt project is focused on the development and application of new biophysical tools for the study of proteins and their complexes. During the first half of the project, good progress has been demonstrated both in the development of new methodologies as well as in their application to study protein-protein interactions. In particular, a new microfluidic platform for measuring the sizes of proteins and their complexes in their native states has been demonstrated; this approach allows us to detect protein-protein interactions directly in solution, without the requirement to immobilise or funcationalise any of the reaction partners. We are now building on these advances to explore a large of biomolecular assembly phenomena, from protein co-factors binding to ribosomes during protein synthesis, to the recognition of misfolded proteins by the cellular quality control machinery.


Renata Schaeffer, (European Policy Manager)
Tel.: +44 1223 333543
Fax: +44 1223 332988
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